2,4-Diaminobutyric acid

2,4-Diaminobutyric acid

2,4-Diaminobutyric acid (also known as DAB) is a diamino acid that is used in the biosynthesis of peptides and proteins. It is a derivative of the amino acid butyric acid, with two amino groups replacing two of the hydrogen atoms.

Structure and properties

2,4-Diaminobutyric acid has a molecular formula of C4H10N2O2. It is a white, crystalline solid that is soluble in water. The presence of two amino groups gives it a strong basicity, and it can form salts with acids.

Biosynthesis

2,4-Diaminobutyric acid is synthesized in the body from oxaloacetic acid through a series of enzymatic reactions. The first step is the transamination of oxaloacetic acid to aspartic acid, followed by the reduction of aspartic acid to 2,4-diaminobutyric acid.

Biological role

2,4-Diaminobutyric acid plays a crucial role in the biosynthesis of proteins and peptides. It is a key component of the peptide bond, which links amino acids together to form proteins. In addition, it is involved in the production of certain neurotransmitters, such as gamma-aminobutyric acid (GABA).

Health effects

While 2,4-Diaminobutyric acid is generally considered safe, excessive intake can lead to health problems. These include neurological disorders, as the compound can interfere with the normal functioning of the nervous system. It can also cause kidney damage due to its high nitrogen content.

See also

• Amino acid
• Peptide bond
• Protein biosynthesis

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