2,8-Dihydroxyhexahydrochrysene

2,8-Dihydroxyhexahydrochrysene is a synthetic, nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol. Despite the fact that it is an estrogen, it has been shown to have anticancer effects in experimental models.

Chemical Structure

2,8-Dihydroxyhexahydrochrysene is a synthetic, nonsteroidal estrogen of the stilbestrol group. It is related to diethylstilbestrol, a type of synthetic estrogen that was widely prescribed to pregnant women from the 1940s to the 1970s. The chemical structure of 2,8-Dihydroxyhexahydrochrysene is similar to that of other stilbestrols, but it has additional hydroxy groups at the 2 and 8 positions.

Pharmacology

As an estrogen, 2,8-Dihydroxyhexahydrochrysene binds to and activates the estrogen receptor, a nuclear transcription factor that is involved in the regulation of gene expression. This can lead to a variety of biological effects, depending on the specific genes that are regulated. In addition to its estrogenic activity, 2,8-Dihydroxyhexahydrochrysene has been shown to have anticancer effects in experimental models. The exact mechanism of this anticancer activity is not fully understood, but it may involve the induction of apoptosis, or programmed cell death.

Clinical Use

2,8-Dihydroxyhexahydrochrysene is not currently used in clinical practice. However, its anticancer effects in experimental models suggest that it may have potential as a therapeutic agent in the treatment of certain types of cancer. Further research is needed to determine the safety and efficacy of this compound in humans.

See Also

• Estrogen receptor
• Diethylstilbestrol
• Stilbestrol
• Cancer

2,8-Dihydroxyhexahydrochrysene Resources
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