2-Chloroamphetamine

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Chemical compound


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2-Chloroamphetamine (also known as 2-CA) is a chemical compound that belongs to the class of substituted amphetamines. It is a derivative of amphetamine where a chlorine atom is substituted at the 2-position of the phenyl ring. This compound is primarily of interest in scientific research due to its pharmacological properties and potential neurotoxicity.

Chemical Structure and Properties[edit | edit source]

2-Chloroamphetamine is characterized by the presence of a chlorine atom attached to the benzene ring of the amphetamine structure. The molecular formula of 2-CA is C9H12ClN, and it has a molecular weight of 169.65 g/mol. The presence of the chlorine atom significantly alters the compound's chemical and physical properties compared to amphetamine.

Pharmacology[edit | edit source]

2-Chloroamphetamine acts primarily as a serotonin releasing agent. It has been shown to increase the release of serotonin from neurons, which can lead to various physiological and psychological effects. The compound has been used in research to study the mechanisms of serotonin release and the effects of serotonin on the brain.

Neurotoxicity[edit | edit source]

One of the significant concerns with 2-Chloroamphetamine is its potential neurotoxic effects. Studies have indicated that it can cause damage to serotonin neurons, similar to other substituted amphetamines like MDMA. This neurotoxicity is thought to be due to the excessive release of serotonin and the subsequent oxidative stress on neurons.

Synthesis[edit | edit source]

The synthesis of 2-Chloroamphetamine involves the chlorination of amphetamine or its precursors. This process typically requires careful control of reaction conditions to ensure the selective substitution of the chlorine atom at the desired position on the phenyl ring.

Legal Status[edit | edit source]

The legal status of 2-Chloroamphetamine varies by country. In many jurisdictions, it is considered a controlled substance due to its structural similarity to amphetamine and its potential for abuse and neurotoxicity.

Research Applications[edit | edit source]

2-Chloroamphetamine is used in scientific research to study the effects of serotonin release and the potential neurotoxic effects of substituted amphetamines. It serves as a tool for understanding the role of serotonin in the brain and the mechanisms underlying amphetamine-induced neurotoxicity.

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