2-Chloromethylpyridine

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2-Chloromethylpyridine

2-Chloromethylpyridine is an organic compound with the chemical formula C6H6ClN. It is a derivative of pyridine, with a chloromethyl group (-CH2Cl) attached to one of the carbon atoms in the pyridine ring.

Chemical Properties

2-Chloromethylpyridine is a colorless liquid at room temperature. It has a strong, unpleasant odor. The compound is soluble in most organic solvents, but is not soluble in water. It is a strong base, due to the presence of the nitrogen atom in the pyridine ring.

Synthesis

2-Chloromethylpyridine can be synthesized by the reaction of pyridine with chloromethane in the presence of a base, such as sodium hydroxide. The reaction proceeds via a nucleophilic substitution mechanism, with the base deprotonating the chloromethane to form a carbanion, which then attacks the pyridine ring.

Uses

2-Chloromethylpyridine is used as a reagent in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block in the synthesis of various heterocyclic compounds.

Safety

2-Chloromethylpyridine is a highly reactive compound and should be handled with care. It can cause burns and eye damage. It is also harmful if inhaled, swallowed, or comes into contact with skin.

See Also

• Pyridine
• Chloromethane
• Nucleophilic substitution