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2-Methoxyamphetamine (2-MA), also known by its chemical name ortho-Methoxyamphetamine, is a psychoactive drug and research chemical belonging to the amphetamine class of compounds. It is known for its stimulant, entactogen, and hallucinogenic effects. The compound is structurally related to other amphetamines such as methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA), and other substituted amphetamines.

Chemistry[edit | edit source]

2-Methoxyamphetamine is an organic compound with the chemical formula C_10H_15NO_2. It features a methoxy group (-OCH_3) attached to the benzene ring of the amphetamine structure at the ortho (2-) position. This modification alters the pharmacological properties of the compound compared to its unsubstituted amphetamine counterparts.

Pharmacology[edit | edit source]

The pharmacological action of 2-MA is primarily due to its activity at various neurotransmitter receptors and transporters. It acts as a releasing agent and reuptake inhibitor for serotonin, dopamine, and norepinephrine, leading to increased concentrations of these neurotransmitters in the synapse. The presence of the methoxy group at the 2-position significantly influences its affinity and selectivity towards these targets.

Effects[edit | edit source]

The effects of 2-Methoxyamphetamine can vary significantly depending on the dose, route of administration, and individual user. Commonly reported effects include stimulation, enhanced mood, increased sociability, euphoria, altered perception of time, and visual hallucinations. Due to its entactogenic properties, it may also promote feelings of empathy and closeness with others. However, adverse effects such as anxiety, paranoia, and psychosis can occur, especially at higher doses or with prolonged use.

Legal Status[edit | edit source]

The legal status of 2-Methoxyamphetamine varies by country, but it has been classified as a controlled substance in several jurisdictions due to its potential for abuse, dependence, and harm. In some countries, it is regulated under analog acts or specific drug legislation targeting psychoactive substances.

Research and Clinical Use[edit | edit source]

As of now, 2-Methoxyamphetamine has limited research data available and is not approved for any clinical use. It has been studied in the context of its pharmacological properties and potential effects on the brain, but further research is needed to fully understand its mechanisms of action and potential therapeutic applications.

Safety and Toxicity[edit | edit source]

The safety profile of 2-MA is not well-established, and there is potential for toxicity, especially with high doses or chronic use. Risks may include cardiovascular issues, neurotoxicity, and psychological effects such as anxiety and psychosis. Users should exercise caution and be aware of the legal and health risks associated with its use.

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Contributors: Prab R. Tumpati, MD