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2-Methyl-5-hydroxytryptamine[edit | edit source]

2-Methyl-5-hydroxytryptamine (2-Me-5-HT) is a tryptamine derivative that is used in scientific research. It acts as a serotonin receptor agonist, specifically at the 5-HT3 receptor and 5-HT4 receptor subtypes.

Structure and Properties[edit | edit source]

2-Methyl-5-hydroxytryptamine is a derivative of the naturally occurring neurotransmitter, serotonin. It has a molecular formula of C11H14N2O and a molecular weight of 190.24 g/mol. The compound is a white to off-white powder and is soluble in water.

Pharmacology[edit | edit source]

2-Methyl-5-hydroxytryptamine acts as an agonist at the 5-HT3 and 5-HT4 receptors, which are subtypes of the serotonin receptor. These receptors are involved in a variety of physiological processes, including the regulation of mood, appetite, and sleep. By activating these receptors, 2-Me-5-HT can mimic the effects of serotonin.

Research Uses[edit | edit source]

2-Methyl-5-hydroxytryptamine is primarily used in scientific research to study the function of the 5-HT3 and 5-HT4 receptors. It can be used in both in vitro and in vivo experiments. For example, it can be used to investigate the role of these receptors in conditions such as depression, anxiety, and irritable bowel syndrome.

Safety and Toxicity[edit | edit source]

As a research chemical, 2-Methyl-5-hydroxytryptamine is not intended for human consumption. However, due to its action on the serotonin system, it could potentially cause side effects similar to those of other serotonin agonists if ingested. These could include nausea, vomiting, and changes in mood or behavior.

See Also[edit | edit source]

References[edit | edit source]

External Links[edit | edit source]


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Contributors: Prab R. Tumpati, MD