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2-Oxo-PCE (also known as Deschloroeticyclidine or O-PCE) is a dissociative anesthetic that has been sold online as a designer drug. It is a structural analog of PCE.

Chemistry[edit | edit source]

2-Oxo-PCE is a arylcyclohexylamine derivative and shares many similarities with ketamine, PCE, and PCP. Its structure consists of a phenyl ring bonded to a cyclohexane ring, but instead of a normal amino group, it contains a ketone group, which is a carbonyl group (C=O) bonded to two other carbon atoms.

Pharmacology[edit | edit source]

As a member of the arylcyclohexylamine class, 2-Oxo-PCE is believed to primarily act as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of normal physical sensation.

Effects[edit | edit source]

The effects of 2-Oxo-PCE are often compared to those of other dissociative anesthetics such as ketamine and PCP. These effects include analgesia, amnesia, delirium, and in some cases hallucinations. It is reported to produce a more potent and longer lasting dissociative state than its relative 2-Oxo-PCM (Deschloroketamine).

Legal Status[edit | edit source]

The legal status of 2-Oxo-PCE varies by country. In some countries, it is a controlled substance, while in others it is legal to possess for personal use.

See Also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD