2-methyl-4-isothiazolin-3-one

2-Methyl-4-isothiazolin-3-one (also known as MIT) is a powerful biocide and preservative used in a variety of products, including personal care products, cleaning products, and industrial applications. It is a member of the isothiazolinone family of biocides.

Chemical Structure and Properties

2-Methyl-4-isothiazolin-3-one is a heterocyclic compound with the molecular formula C4H5NOS. It is a colorless to pale yellow liquid with a slight odor. It is soluble in water and most organic solvents. The compound is a strong oxidizing agent and can cause burns and eye damage.

Uses

2-Methyl-4-isothiazolin-3-one is primarily used as a biocide and preservative in a variety of products. It is effective against a broad spectrum of microorganisms, including bacteria, yeasts, and molds. It is used in personal care products such as shampoos, conditioners, and body washes, as well as in cleaning products and industrial applications.

Health Effects

Exposure to 2-Methyl-4-isothiazolin-3-one can cause skin irritation and allergic reactions. It can also cause serious eye damage. Long-term exposure can lead to sensitization and allergic contact dermatitis. The European Chemicals Agency (ECHA) has classified 2-Methyl-4-isothiazolin-3-one as a substance of very high concern due to its sensitizing properties.

Regulation

In the European Union, the use of 2-Methyl-4-isothiazolin-3-one in leave-on cosmetic products is restricted to a maximum concentration of 0.01%. In the United States, the Food and Drug Administration (FDA) has not set a specific limit for the use of 2-Methyl-4-isothiazolin-3-one in cosmetics, but it requires that all cosmetic ingredients be safe for use.

See Also

• Isothiazolinone
• Biocide
• Preservative
• European Chemicals Agency
• Food and Drug Administration