24S-Hydroxycholesterol
24S-Hydroxycholesterol (also known as Cerebrosterol) is a sterol that is synthesized from cholesterol in the brain by the enzyme cholesterol 24-hydroxylase. It is an important component of the brain's lipid metabolism and plays a crucial role in maintaining the health and function of neurons.
Function[edit | edit source]
24S-Hydroxycholesterol is involved in the regulation of cholesterol homeostasis in the brain. It is synthesized from cholesterol by the enzyme cholesterol 24-hydroxylase, which is expressed in neurons. The production of 24S-Hydroxycholesterol allows for the excess cholesterol in the brain to be eliminated.
In addition to its role in cholesterol homeostasis, 24S-Hydroxycholesterol has been found to have other functions in the brain. It has been shown to modulate the activity of NMDA receptors, which are involved in synaptic plasticity, a process that is important for learning and memory.
Clinical significance[edit | edit source]
Abnormal levels of 24S-Hydroxycholesterol have been associated with a number of neurological disorders, including Alzheimer's disease, Huntington's disease, and Parkinson's disease. In these conditions, the levels of 24S-Hydroxycholesterol in the blood and cerebrospinal fluid are often elevated, suggesting a disruption in cholesterol homeostasis in the brain.
See also[edit | edit source]
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