3α-androsterone sulfate
3α-Androsterone sulfate is a sulfate conjugate of the androgenic steroid 3α-androsterone. It is a naturally occurring metabolite of testosterone and other androgens, and it is found in human urine and blood plasma.
Biochemistry[edit | edit source]
3α-Androsterone sulfate is formed from 3α-androsterone through the action of sulfotransferase enzymes, which transfer a sulfate group to the hydroxyl group of 3α-androsterone. This process increases the solubility of the steroid in water, facilitating its excretion from the body.
In the body, 3α-androsterone sulfate can be converted back to 3α-androsterone by the action of sulfatase enzymes, which remove the sulfate group. This reversible conversion plays a role in the regulation of androgenic activity in various tissues.
Physiological Role[edit | edit source]
3α-Androsterone sulfate, like other steroid sulfates, serves as a reservoir of inactive steroids that can be converted to active forms when needed. It is considered to have weak androgenic activity on its own, but it can be converted to more potent androgens such as dihydrotestosterone (DHT) in target tissues.
The levels of 3α-androsterone sulfate in the body can be influenced by various factors, including age, sex, and hormonal status. It is often measured in clinical settings to assess androgen metabolism and to diagnose disorders of steroidogenesis.
Clinical Significance[edit | edit source]
Abnormal levels of 3α-androsterone sulfate can be indicative of certain medical conditions. Elevated levels may be associated with polycystic ovary syndrome (PCOS), congenital adrenal hyperplasia, or androgen-secreting tumors. Conversely, low levels may be seen in conditions such as hypogonadism or adrenal insufficiency.
Measurement[edit | edit source]
3α-Androsterone sulfate levels can be measured in blood or urine samples using techniques such as liquid chromatography-mass spectrometry (LC-MS) or radioimmunoassay (RIA). These measurements can provide valuable information about an individual's androgen status and help guide clinical management.
Also see[edit | edit source]
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