3,3',5-Triiodothyronamine

3,3',5-Triiodothyronamine (also known as T1AM) is a metabolite of the thyroid hormone thyroxine (T4). It is a naturally occurring amine that is derived from deiodination of thyroxine (T4) and triiodothyronine (T3).

Structure and Function

The structure of 3,3',5-triiodothyronamine is similar to that of the thyroid hormones, but it has one less iodine atom. It is a small molecule with a molecular weight of approximately 650 Daltons. The function of T1AM is not fully understood, but it is known to have a significant impact on the central nervous system and cardiovascular system.

Metabolism

3,3',5-Triiodothyronamine is primarily produced in the liver and kidney through the process of deiodination. This process involves the removal of an iodine atom from thyroxine (T4) or triiodothyronine (T3) by deiodinase enzymes. The resulting metabolite, T1AM, is then released into the bloodstream.

Biological Effects

T1AM has been shown to have several biological effects. It can act as a neurotransmitter, influencing the function of the central nervous system. It has also been shown to have a significant impact on the cardiovascular system, influencing heart rate and blood pressure. Additionally, T1AM has been shown to influence metabolism, potentially playing a role in weight regulation.

Clinical Significance

The clinical significance of 3,3',5-triiodothyronamine is still being explored. It has been suggested that alterations in T1AM levels could be associated with various diseases, including hypothyroidism, hyperthyroidism, and cardiovascular disease. However, more research is needed to fully understand the role of T1AM in health and disease.

See Also

• Thyroid hormone
• Thyroxine
• Triiodothyronine
• Deiodinase