3,4-Methylenedioxyphenylpropan-2-one

MDP2P.svg

3,4-Methylenedioxyphenylpropan-2-one (MDP2P), also known as piperonyl methyl ketone (PMK), is an organic compound with the molecular formula C₁₀H₁₀O₃. It is a key intermediate in the synthesis of the psychoactive drug MDMA (3,4-methylenedioxy-N-methylamphetamine), commonly known as ecstasy.

Chemical Properties

3,4-Methylenedioxyphenylpropan-2-one is a colorless to pale yellow liquid with a density of 1.205 g/cm³. It has a melting point of 7.5 °C and a boiling point of 290 °C. The compound is characterized by the presence of a methylenedioxy group attached to a phenyl ring, which is further connected to a propan-2-one moiety.

Synthesis

MDP2P can be synthesized through several methods, including the Wacker oxidation of safrole or isomerization of isosafrole. These methods are often employed in clandestine laboratories due to the compound's role as a precursor in the illicit production of MDMA.

Legal Status

Due to its use in the synthesis of MDMA, 3,4-methylenedioxyphenylpropan-2-one is classified as a List I chemical under the United States Controlled Substances Act. This classification imposes strict regulatory controls on its manufacture, distribution, and possession.

Applications

While its primary notoriety comes from its role in the synthesis of MDMA, MDP2P also has legitimate applications in the synthesis of other chemicals and pharmaceuticals. However, its legal status significantly restricts its availability and use.

Safety and Handling

MDP2P is classified as a hazardous substance and should be handled with care. It has a flash point of 127 °C, indicating that it can form flammable vapors at relatively low temperatures. Appropriate safety measures, including the use of personal protective equipment and proper ventilation, should be employed when handling this compound.

See Also

• MDMA
• Safrole
• Isosafrole
• Wacker oxidation
• List I chemicals