3-HO-PCP

3-HO-PCP is a dissociative anesthetic drug that has been sold online as a designer drug. The compound was first synthesized in 1978 to investigate the structure-activity relationship of phencyclidine derivatives. The activity of 3-HO-PCP in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle reported qualitative similarities to PCP.

Chemistry[edit | edit source]

3-HO-PCP is an arylcyclohexylamine derivative and shares many features with other substances of this class. It is closely related to 3-MeO-PCP and PCP.

Pharmacology[edit | edit source]

As with other arylcyclohexylamine derivatives, the pharmacological action of 3-HO-PCP is believed to result primarily from NMDA receptor antagonism. Other factors, such as opioid receptor affinity could potentially be involved in the drug's effects.

Effects[edit | edit source]

The effects of 3-HO-PCP can vary greatly depending on the dose, but may include dissociation, hallucinations, analgesia, sedation, amnesia, and euphoria. It is often described as being more potent than PCP.

Legality[edit | edit source]

3-HO-PCP is illegal in many countries due to its potential for abuse and health risks. It is classified as a Schedule I substance in the United States.

See also[edit | edit source]

3-HO-PCP Resources
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