3-Iodotyrosine

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(S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic_acid_200.svg

3-Iodotyrosine is an iodinated derivative of the amino acid tyrosine. It is an important intermediate in the synthesis of thyroid hormones such as triiodothyronine (T3) and thyroxine (T4).

Synthesis and Function

3-Iodotyrosine is synthesized in the thyroid gland through the iodination of tyrosine residues in the protein thyroglobulin. This process is catalyzed by the enzyme thyroid peroxidase. The iodination of tyrosine can result in the formation of either 3-iodotyrosine or 3,5-diiodotyrosine, both of which are precursors to the thyroid hormones.

Role in Thyroid Hormone Production

In the thyroid gland, 3-iodotyrosine combines with 3,5-diiodotyrosine to form triiodothyronine (T3), or with another molecule of 3-iodotyrosine to form thyroxine (T4). These hormones are critical for regulating metabolism, growth, and development.

Clinical Significance

Abnormalities in the production or metabolism of 3-iodotyrosine can lead to various thyroid disorders, including hypothyroidism and hyperthyroidism. Understanding the role of 3-iodotyrosine in thyroid hormone synthesis is essential for diagnosing and treating these conditions.

See Also

• Tyrosine
• Thyroid gland
• Thyroid hormone
• Thyroid peroxidase
• Triiodothyronine
• Thyroxine