3-Iodotyrosine
-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic_acid_200.svg)
Chemical compound
| Chemical Compound | |
|---|---|
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| ChemSpider ID | |
| UNII | |
| ChEBI | |
| ChEMBL | |
| Properties | |
| Chemical Formula | |
| Molar Mass | |
| Appearance | |
| Density | |
| Melting Point | |
| Boiling Point | |
| Hazards | |
| GHS Pictograms | [[File:|50px]] |
| GHS Signal Word | |
| GHS Hazard Statements | |
| NFPA 704 | [[File:|50px]] |
| References | |
3-Iodotyrosine is an iodinated derivative of the amino acid tyrosine. It is an important intermediate in the synthesis of thyroid hormones such as triiodothyronine (T3) and thyroxine (T4).
Synthesis and Function[edit | edit source]
3-Iodotyrosine is synthesized in the thyroid gland through the iodination of tyrosine residues in the protein thyroglobulin. This process is catalyzed by the enzyme thyroid peroxidase. The iodination of tyrosine can result in the formation of either 3-iodotyrosine or 3,5-diiodotyrosine, both of which are precursors to the thyroid hormones.
Role in Thyroid Hormone Production[edit | edit source]
In the thyroid gland, 3-iodotyrosine combines with 3,5-diiodotyrosine to form triiodothyronine (T3), or with another molecule of 3-iodotyrosine to form thyroxine (T4). These hormones are critical for regulating metabolism, growth, and development.
Clinical Significance[edit | edit source]
Abnormalities in the production or metabolism of 3-iodotyrosine can lead to various thyroid disorders, including hypothyroidism and hyperthyroidism. Understanding the role of 3-iodotyrosine in thyroid hormone synthesis is essential for diagnosing and treating these conditions.
See Also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
