3-Phenylpropanoylfentanyl

3-Phenylpropanoylfentanyl is a potent synthetic opioid that is an analog of fentanyl. It is part of the fentanyl analogues group, which are modified versions of fentanyl designed to mimic its potent analgesic effects.

Chemistry

3-Phenylpropanoylfentanyl is a fentanyl analog where the propionyl group attached to the nitrogen atom is replaced by a phenylpropanoyl group. This modification does not significantly alter the opioid receptor binding affinity of the compound, making it similarly potent to fentanyl.

Pharmacology

Like other fentanyl analogs, 3-Phenylpropanoylfentanyl acts primarily as an agonist at the mu-opioid receptor. This receptor is responsible for the analgesic effects of opioids. The binding of 3-Phenylpropanoylfentanyl to the mu-opioid receptor triggers a cascade of events leading to analgesia, sedation, and other effects characteristic of opioid drugs.

Effects

The effects of 3-Phenylpropanoylfentanyl are similar to those of other potent opioids. These include strong analgesia, sedation, euphoria, constipation, itching, and respiratory depression. Due to its high potency, the risk of overdose and death is significantly higher than with less potent opioids.

Legal Status

3-Phenylpropanoylfentanyl is a controlled substance in many countries due to its potential for abuse and the public health risks associated with its use. In the United States, it is a Schedule I controlled substance under the Controlled Substances Act.

See Also

• Fentanyl
• Opioid
• Opioid receptor
• Analgesic

References

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