3F8
3F8 is a monoclonal antibody used in the treatment of neuroblastoma, a type of cancer that arises from nerve tissue. This antibody specifically targets the GD2 antigen, which is highly expressed on the surface of neuroblastoma cells.
Mechanism of Action[edit | edit source]
3F8 works by binding to the GD2 antigen on the surface of neuroblastoma cells. This binding triggers an immune response, leading to the destruction of the cancer cells. The immune response is primarily mediated by antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).
Clinical Use[edit | edit source]
3F8 has been used in clinical trials and treatments primarily for patients with high-risk neuroblastoma. It is often administered in combination with other treatments such as chemotherapy, radiation therapy, and stem cell transplantation to improve outcomes.
Side Effects[edit | edit source]
The administration of 3F8 can lead to several side effects, including:
- Pain at the site of infusion
- Fever
- Hypertension
- Allergic reactions
Research and Development[edit | edit source]
3F8 was developed by researchers at Memorial Sloan Kettering Cancer Center. Ongoing research aims to improve the efficacy and reduce the side effects of this treatment. Newer versions and derivatives of 3F8 are also being explored.
See Also[edit | edit source]
- Neuroblastoma
- Monoclonal antibody therapy
- GD2
- Antibody-dependent cellular cytotoxicity
- Complement-dependent cytotoxicity
References[edit | edit source]
External Links[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
