4'-Methyl-alpha-pyrrolidinohexiophenone

4'-Methyl-alpha-pyrrolidinohexiophenone (MPHP) is a synthetic stimulant of the cathinone class that has been sold online as a designer drug. It is a derivative of pyrovalerone, featuring the pyrrolidinophenone side chain found in other synthetic cathinone derivatives, including MDPV (Methylenedioxypyrovalerone) and α-PVP (Alpha-Pyrrolidinopentiophenone). Due to its structure, MPHP is believed to act as a norepinephrine-dopamine reuptake inhibitor, though its exact pharmacological properties and effects in humans are not well-documented due to its status as a novel psychoactive substance (NPS).

Chemistry

MPHP is a member of the cathinone class, which are beta-ketone analogues of amphetamines. Its molecular structure includes a phenyl ring core with an attached pyrrolidinyl group and an alkyl chain of varying length, in this case, hexyl. The '4'-methyl' substitution on the phenyl ring distinguishes MPHP from its close relatives in the synthetic cathinone family.

Pharmacology

The pharmacological activity of MPHP is primarily attributed to its action as a reuptake inhibitor for the neurotransmitters dopamine and norepinephrine, leading to increased concentrations of these neurotransmitters in the synaptic cleft and consequently, stimulation of the central nervous system. This mechanism of action is similar to other synthetic cathinones and traditional stimulants like cocaine and amphetamines. However, the lack of comprehensive studies on MPHP means that its efficacy, potency, and safety profile remain largely unknown.

Legal Status

The legal status of MPHP varies by country, with several jurisdictions having moved to control the substance in response to its emergence on the recreational drug market. It is often listed as a controlled substance under analog acts or specific legislation aimed at curbing the distribution and use of synthetic cathinones. Users and distributors may face legal penalties for possession, distribution, or manufacture of MPHP depending on local laws.

Health Risks

As with many NPS, the health risks associated with MPHP use are not fully understood. However, it is reasonable to assume that its effects and risks are similar to those of other stimulants in its class, which can include cardiovascular issues, neurological effects, and potential for abuse and addiction. The absence of clinical studies and reliable user reports makes it difficult to assess the specific health implications of MPHP.

See Also

• Cathinone
• Synthetic cathinones
• Pyrovalerone
• MDPV
• α-PVP