4-Ethylphenyl sulfate

4-Ethylphenyl sulfate is a sulfate compound that is produced by the human body. It is a metabolite of the microbiome, the community of microorganisms that live in the human gut.

Chemistry

4-Ethylphenyl sulfate is a sulfate ester of 4-ethylphenol. It has a molecular formula of C8H10O4S. The compound is a derivative of phenol, with an ethyl group attached to the fourth carbon atom in the phenol ring. The sulfate group is attached to the hydroxyl group of the phenol.

Biosynthesis

The biosynthesis of 4-ethylphenyl sulfate is carried out by gut bacteria. The bacteria metabolize dietary tyrosine, an amino acid, to produce 4-ethylphenol. The 4-ethylphenol is then sulfated by the human body to produce 4-ethylphenyl sulfate.

Role in the body

4-Ethylphenyl sulfate has been found to play a role in the development of Parkinson's disease. Studies have shown that levels of 4-ethylphenyl sulfate are significantly higher in individuals with Parkinson's disease compared to healthy individuals. It is thought that the compound may contribute to the neurodegeneration seen in Parkinson's disease by causing inflammation and oxidative stress.

See also

• Microbiome
• Parkinson's disease
• Tyrosine
• Phenol

References

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