4-Fluoroselegiline

4-Fluoroselegiline is a fluorinated derivative of the monoamine oxidase inhibitor (MAOI) selegiline. It is a selective inhibitor of monoamine oxidase B (MAO-B), an enzyme that breaks down dopamine in the brain.

Pharmacology

4-Fluoroselegiline is a reversible inhibitor of MAO-B, meaning it binds to the enzyme and prevents it from breaking down dopamine. This increases the amount of dopamine available in the brain, which can help to alleviate symptoms of Parkinson's disease and other neurodegenerative diseases.

The fluorine atom in 4-Fluoroselegiline increases its lipophilicity, allowing it to cross the blood-brain barrier more easily than selegiline. This means it can have a more potent effect on the brain.

Clinical Use

4-Fluoroselegiline is not currently approved for use in humans. However, it has been studied in animal models of Parkinson's disease and has shown promise as a potential treatment. Further research is needed to determine its safety and efficacy in humans.

Side Effects

As with other MAOIs, 4-Fluoroselegiline can cause a range of side effects. These can include insomnia, nausea, dizziness, and orthostatic hypotension. It can also interact with certain foods and other medications, leading to potentially serious drug interactions.

See Also

• Selegiline
• Monoamine oxidase inhibitor
• Parkinson's disease