Monoamine oxidase B
Monoamine oxidase B (MAO-B) is an enzyme that is part of the monoamine oxidase family. It is encoded in humans by the MAOB gene and is involved in the breakdown of neurotransmitters in the brain, particularly dopamine, norepinephrine, and serotonin.
Function[edit | edit source]
MAO-B is found in the mitochondria of most cell types in the body. It is especially abundant in the liver, platelets, and neurons of the central nervous system. The enzyme's primary function is to catalyze the oxidation of monoamines, a type of neurotransmitter. This process is crucial for maintaining proper brain function and regulating mood.
Clinical significance[edit | edit source]
Abnormal levels of MAO-B have been linked to several neurological disorders. High levels of the enzyme have been found in patients with Parkinson's disease, suggesting that MAO-B may play a role in the disease's progression. In contrast, low levels of MAO-B have been associated with depression and anxiety disorders.
Inhibitors[edit | edit source]
MAO inhibitors are a class of drugs that block the action of monoamine oxidases. MAO-B inhibitors specifically target MAO-B and are used to treat symptoms of Parkinson's disease. These drugs work by preventing the breakdown of dopamine, thereby increasing its availability in the brain.
See also[edit | edit source]
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Usage[edit source]The Template:They is used in place of gender-specific pronouns when the gender of the person referred to is unknown, irrelevant, or when the person prefers they/them pronouns. It is also used when referring to a generic or hypothetical person whose gender is not specified. To use the template, editors simply include Template loop detected: Template:They in the text where they would normally use a pronoun. The template then renders as "they" in the published article. Background[edit source]The use of "they" as a singular pronoun has a long history in the English language. However, its use has become more prominent and politically significant in recent years due to growing awareness and acceptance of non-binary and genderqueer identities. The Template:They is part of a suite of templates designed to promote gender-neutral language on Wikipedia. Other related templates include Template:Them and Template:Their, which render as "them" and "their" respectively. Controversy[edit source]While the use of Template:They is generally accepted within the Wikipedia community, it has been the subject of some controversy. Critics argue that the use of "they" as a singular pronoun can be grammatically confusing or incorrect. However, proponents argue that it is a necessary and respectful way to acknowledge non-binary and genderqueer individuals. See also[edit source]
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