N-Methyltryptamine

N-Methyltryptamine (NMT) is a member of the tryptamine chemical class and a natural product which is biosynthesized in organisms as diverse as plants, fungi, and animals. It is a common component of human urine and has been found in trace amounts in the brain tissue of mammals.

Chemistry

N-Methyltryptamine is a tryptamine derivative closely related to the neurotransmitter serotonin and the psychedelic DMT. It is a mono-methylated tryptamine, structurally similar to other mono-methylated tryptamines such as bufotenin and 5-MeO-DMT.

Biosynthesis

N-Methyltryptamine is biosynthesized via the action of the enzyme tryptamine N-methyltransferase on tryptamine. This is the first step in the biosynthesis of dimethyltryptamine (DMT) in certain organisms.

Pharmacology

The pharmacology of N-methyltryptamine is not well studied. It is known to act as a non-selective serotonin receptor agonist, and also affects the levels of monoamine neurotransmitters by inhibiting monoamine oxidase (MAO) and promoting neurotransmitter release.

See also

• Tryptamine
• Dimethyltryptamine
• Serotonin
• Monoamine neurotransmitters

References

N-Methyltryptamine Resources
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