6-Hydroxymelatonin
Chemical compound
| IUPAC Name: | {{{IUPACName}}} |
| Other Names: | |
| Identifiers | |
| CAS Number | |
| PubChem | |
| ChemSpider | |
| SMILES | |
| InChI | |
| InChIKey | |
| StdInChI | |
| StdInChIKey | |
| Properties | |
| Chemical formula | CHNO |
| Appearance | |
| Density | |
| Melting Point | |
| Boiling Point | |
| Solubility | |
| Hazards | |
| Main Hazards | |
| Flash Point | |
| Autoignition Temperature | |
6-Hydroxymelatonin is a chemical compound that is a metabolite of the hormone melatonin. It is produced in the liver through the process of hydroxylation by the enzyme cytochrome P450.
Biological Role[edit | edit source]
6-Hydroxymelatonin plays a role in the regulation of the circadian rhythm and has been studied for its potential antioxidant properties. It is one of the primary metabolites of melatonin, along with N-acetylserotonin.
Metabolism[edit | edit source]
The metabolism of melatonin to 6-hydroxymelatonin occurs primarily in the liver. The enzyme cytochrome P450, specifically the CYP1A2 isoform, is responsible for the hydroxylation of melatonin at the 6-position. This process converts melatonin into 6-hydroxymelatonin, which is then further metabolized to 6-sulfatoxymelatonin.
Clinical Significance[edit | edit source]
6-Hydroxymelatonin has been studied for its potential use as a biomarker for melatonin levels in the body. Its levels can be measured in urine to assess the pineal gland's production of melatonin. This can be useful in diagnosing and monitoring disorders related to melatonin production, such as sleep disorders and certain types of depression.
Research[edit | edit source]
Research into 6-hydroxymelatonin has explored its potential neuroprotective effects and its role in oxidative stress. Studies have suggested that it may help protect against neurodegenerative diseases by reducing oxidative damage in the brain.
See also[edit | edit source]
References[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
