6-Hydroxymelatonin

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6-Hydroxymelatonin is a chemical compound that is a metabolite of the hormone melatonin. It is produced in the liver through the process of hydroxylation by the enzyme cytochrome P450.

Biological Role

6-Hydroxymelatonin plays a role in the regulation of the circadian rhythm and has been studied for its potential antioxidant properties. It is one of the primary metabolites of melatonin, along with N-acetylserotonin.

Metabolism

The metabolism of melatonin to 6-hydroxymelatonin occurs primarily in the liver. The enzyme cytochrome P450, specifically the CYP1A2 isoform, is responsible for the hydroxylation of melatonin at the 6-position. This process converts melatonin into 6-hydroxymelatonin, which is then further metabolized to 6-sulfatoxymelatonin.

Clinical Significance

6-Hydroxymelatonin has been studied for its potential use as a biomarker for melatonin levels in the body. Its levels can be measured in urine to assess the pineal gland's production of melatonin. This can be useful in diagnosing and monitoring disorders related to melatonin production, such as sleep disorders and certain types of depression.

Research

Research into 6-hydroxymelatonin has explored its potential neuroprotective effects and its role in oxidative stress. Studies have suggested that it may help protect against neurodegenerative diseases by reducing oxidative damage in the brain.

See also

• Melatonin
• Circadian rhythm
• Cytochrome P450
• Antioxidant

References

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