4-HO-αMT

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4-HO-αMT (also known as 4-Hydroxy-α-methyltryptamine) is a psychedelic drug and a serotonin receptor agonist. It is a close structural and functional analog of psilocin, the active ingredient in psilocybin mushrooms, and is often used as a substitute in scientific research.

Chemistry[edit | edit source]

4-HO-αMT is a tryptamine, a class of compounds that share a common basic structure and are found in a variety of plants, animals, and even within the human body. The chemical structure of 4-HO-αMT includes a indole ring, attached to an amino (NH2) group via an ethyl side chain. The '4-HO' in its name refers to a hydroxy (-OH) group attached at the 4-position of the indole ring, and the 'αMT' refers to the alpha-methyltryptamine backbone of the molecule.

Pharmacology[edit | edit source]

As a serotonin receptor agonist, 4-HO-αMT mimics the action of serotonin in the brain. It binds to and activates the 5-HT2A receptor, the primary target of psychedelic drugs. This receptor is involved in a range of physiological and behavioral functions, including mood, cognition, and perception.

Effects[edit | edit source]

The effects of 4-HO-αMT are similar to those of other psychedelic tryptamines, and can include visual and auditory hallucinations, altered thought processes, and a distorted sense of time. The intensity and duration of these effects can vary depending on the dose and individual user's physiology.

Legal Status[edit | edit source]

The legal status of 4-HO-αMT varies by country. In some countries, it is a controlled substance, while in others it is legal to possess and use.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD