4-Hydroxy-2-nonenal

4-Hydroxy-2-nonenal (also known as 4-HNE or 4-Hydroxynonenal) is a highly reactive aldehyde produced as a byproduct of lipid peroxidation, a process that occurs when free radicals steal electrons from the lipids in cell membranes. This compound is considered a major product of oxidative stress and plays a significant role in various biological processes, including cell signaling, gene expression, and apoptosis.

Structure and Properties

4-Hydroxy-2-nonenal is a nine-carbon aldehyde with a hydroxyl group on the fourth carbon and a double bond between the second and third carbons. It is a highly reactive compound due to the presence of both the aldehyde group and the double bond, which can undergo various reactions such as Michael addition and Schiff base formation.

Production

4-Hydroxy-2-nonenal is primarily produced during the peroxidation of polyunsaturated fatty acids (PUFAs). This process is initiated by the abstraction of a hydrogen atom from the methylene group of PUFAs by free radicals, leading to the formation of lipid radicals. These radicals react with molecular oxygen to form lipid peroxyl radicals, which then undergo a series of reactions to produce 4-Hydroxy-2-nonenal.

Biological Role

4-Hydroxy-2-nonenal plays a significant role in various biological processes. It is involved in cell signaling, where it can modulate the activity of various proteins and enzymes. It also plays a role in gene expression, where it can influence the transcription of various genes. In addition, 4-Hydroxy-2-nonenal is involved in apoptosis, where it can induce cell death.

Health Implications

Due to its high reactivity, 4-Hydroxy-2-nonenal can react with various biomolecules, leading to cellular damage. This has been implicated in various diseases, including cardiovascular disease, neurodegenerative disease, and cancer. However, it also has potential therapeutic applications, as its ability to induce apoptosis could be harnessed for the treatment of cancer.

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