4-Hydroxyestradiol

4-Hydroxyestradiol (also known as 4-OHE2) is a type of estrogen metabolite. It is formed from estradiol in the body, specifically in the liver, by the enzyme cytochrome P450 1B1 (CYP1B1).

Metabolism

4-Hydroxyestradiol is metabolized from estradiol by the enzyme CYP1B1. This enzyme is part of the cytochrome P450 family, which is involved in the metabolism of various molecules and chemicals within cells. CYP1B1 is specifically involved in the metabolism of estrogens, which are important hormones in the body.

Biological activity

4-Hydroxyestradiol has been found to have estrogenic activity, meaning it can interact with estrogen receptors and produce estrogen-like effects. However, its activity is much less than that of estradiol, the primary estrogen in the body.

Health implications

4-Hydroxyestradiol has been implicated in various health conditions. It has been found to be elevated in patients with breast cancer, suggesting it may play a role in the development of this disease. It has also been associated with other types of cancer, including ovarian cancer and endometrial cancer.

See also

• Estradiol
• Estrogen
• Cytochrome P450
• Breast cancer
• Ovarian cancer
• Endometrial cancer

4-Hydroxyestradiol Resources
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