4-Keto-PCP

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4-Keto-PCP is a dissociative anesthetic drug that belongs to the arylcyclohexylamine class. It is chemically related to phencyclidine (PCP) and ketamine, both of which are well-known for their dissociative effects. The compound is known for its potent psychoactive properties and has been used in scientific research to study the NMDA receptor and its role in the central nervous system.

Chemical Structure and Properties

4-Keto-PCP is structurally similar to PCP, with the primary difference being the presence of a ketone group at the fourth position of the cyclohexyl ring. This modification alters its pharmacological profile, making it distinct from other arylcyclohexylamines. The chemical formula for 4-Keto-PCP is C17H23NO, and its molecular weight is 257.37 g/mol.

Pharmacology

4-Keto-PCP acts primarily as an NMDA receptor antagonist, which inhibits the action of the neurotransmitter glutamate at this receptor site. This inhibition leads to the dissociative effects commonly associated with the drug, including altered sensory perception, detachment from reality, and analgesia. The compound may also interact with other receptor systems, including the dopamine and serotonin receptors, contributing to its complex pharmacological profile.

Effects

The effects of 4-Keto-PCP are similar to those of other dissociative anesthetics. Users may experience a range of effects, including:

• Dissociation and detachment from the environment
• Altered perception of time and space
• Euphoria or dysphoria
• Analgesia
• Cognitive and memory impairment

Risks and Side Effects

The use of 4-Keto-PCP carries several risks and potential side effects. Acute effects can include tachycardia, hypertension, and nausea. Chronic use may lead to more severe consequences such as neurotoxicity, psychosis, and addiction. Due to its potent effects and potential for abuse, 4-Keto-PCP is considered a substance of concern in many jurisdictions.

Legal Status

The legal status of 4-Keto-PCP varies by country. In some regions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. In other areas, it may be regulated under analog laws that control substances similar to those already scheduled.

Research

Research on 4-Keto-PCP has primarily focused on its pharmacological properties and potential therapeutic applications. Studies have explored its effects on the NMDA receptor and its potential use in treating conditions such as chronic pain and depression. However, due to its high potential for abuse and adverse effects, its use in clinical settings remains limited.

See Also

• Phencyclidine
• Ketamine
• Dissociative
• NMDA receptor antagonist
• Arylcyclohexylamine