4-Nitroquinoline 1-oxide

4-Nitroquinoline 1-oxide‏‎

4-Nitroquinoline 1-oxide‏‎, also known as 4-NQO, is a chemical compound that is commonly used in laboratory research to induce tumors in experimental animals. It is a potent mutagen and carcinogen that has been extensively studied for its effects on DNA damage and cancer development.

Chemical Properties

4-Nitroquinoline 1-oxide‏‎ has a molecular formula of C9H6N2O3 and a molecular weight of 190.15 g/mol. It is a yellow crystalline solid that is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol. The compound is highly reactive and can undergo metabolic activation to form reactive intermediates that can bind to DNA and cause mutations.

Biological Effects

Studies have shown that exposure to 4-Nitroquinoline 1-oxide‏‎ can lead to the formation of DNA adducts, which are chemical modifications of DNA that can interfere with normal cellular processes. These DNA adducts can result in mutations that may contribute to the development of cancer. Additionally, 4-NQO has been shown to induce oxidative stress and inflammation in cells, further promoting carcinogenesis.

Research Applications

Due to its potent mutagenic and carcinogenic properties, 4-Nitroquinoline 1-oxide‏‎ is widely used in research settings to study the mechanisms of chemical carcinogenesis and DNA damage. Researchers use 4-NQO to induce tumors in animal models and investigate the effects of DNA adduct formation on cancer development. Studies with 4-NQO have provided valuable insights into the molecular pathways involved in carcinogenesis and have helped identify potential targets for cancer therapy.