5α-Dihydronorethisterone
5α-Dihydronorethisterone (also known as 5α-DHN) is a major active metabolite of the synthetic progestin norethisterone. It is formed from norethisterone in the body by the action of 5α-reductase, an enzyme involved in steroid metabolism.
Chemistry[edit | edit source]
5α-Dihydronorethisterone, also known as 5α-DHN, is a steroid and a derivative of progesterone. It is more specifically a derivative of 19-nortestosterone and is a member of the estrane (C18 steroid) group of steroids. Other related steroids include nandrolone, ethisterone, and levonorgestrel.
Pharmacology[edit | edit source]
5α-Dihydronorethisterone is a potent progestogen, or an agonist of the progesterone receptor. It has about 3 to 4 times the potency of its parent compound, norethisterone, in terms of progestogenic activity. The metabolite is also an antagonist of the androgen receptor, the biological target of androgens like testosterone and dihydrotestosterone.
Clinical significance[edit | edit source]
The clinical significance of 5α-Dihydronorethisterone is that it contributes to the progestogenic and antiandrogenic activities of norethisterone. This is relevant in the context of the use of norethisterone in hormone replacement therapy and contraceptives.
See also[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
