5,6-Dihydroxytryptamine
5,6-Dihydroxytryptamine (5,6-DHT) is a chemical compound that is structurally related to the neurotransmitter serotonin. It is primarily used in scientific research to study the function of serotonergic neurons in the brain. 5,6-DHT is a neurotoxin that selectively targets and destroys serotonergic neurons, making it a valuable tool for understanding the role of serotonin in various physiological and behavioral processes.
Chemical Structure and Properties[edit | edit source]
5,6-Dihydroxytryptamine is a derivative of tryptamine, which is a monoamine alkaloid. The chemical structure of 5,6-DHT includes a tryptamine backbone with two hydroxyl groups attached at the 5 and 6 positions of the indole ring. This modification is responsible for its neurotoxic properties.
- IUPAC name: 3-(2-aminoethyl)-1H-indole-5,6-diol
- Molecular formula: C10H12N2O2
- Molar mass: 192.22 g/mol
Mechanism of Action[edit | edit source]
5,6-Dihydroxytryptamine exerts its effects by being taken up into serotonergic neurons via the serotonin transporter (SERT). Once inside the neuron, it undergoes oxidation to form reactive quinone species, which lead to the destruction of the neuron. This selective neurotoxicity allows researchers to create animal models with reduced serotonergic function to study the effects of serotonin depletion.
Applications in Research[edit | edit source]
5,6-DHT is used in experimental settings to:
- Investigate the role of serotonin in mood regulation, anxiety, and depression.
- Study the effects of serotonin depletion on circadian rhythms and sleep.
- Explore the involvement of serotonin in pain perception and nociception.
- Examine the impact of serotonergic dysfunction in neurodegenerative diseases such as Parkinson's disease.
Safety and Handling[edit | edit source]
Due to its neurotoxic properties, 5,6-DHT must be handled with care in a laboratory setting. Appropriate safety measures, including the use of personal protective equipment and proper disposal procedures, are essential to prevent accidental exposure.
Also see[edit | edit source]
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