5-(2-Aminopropyl)indole
5-(2-Aminopropyl)indole (also known as 5-IT, 5-API, or Indopan) is a psychoactive drug and research chemical belonging to the tryptamine family. It is structurally related to dimethyltryptamine (DMT), a naturally occurring psychedelic compound, and amphetamine, a potent central nervous system stimulant.
History[edit | edit source]
5-(2-Aminopropyl)indole was first synthesized in the 1960s by the pharmaceutical company Upjohn as a potential antidepressant medication. However, it did not enter clinical use and remained largely obscure until the 2010s, when it emerged on the designer drug market.
Pharmacology[edit | edit source]
The exact mechanism of action of 5-(2-Aminopropyl)indole is not fully understood. It is believed to act as a serotonin reuptake inhibitor and releasing agent, increasing the levels of serotonin in the brain. This can result in mood elevation, increased energy, and altered perception. However, due to its structural similarity to amphetamine, it may also have stimulant effects.
Effects[edit | edit source]
The effects of 5-(2-Aminopropyl)indole can vary widely depending on the dose, individual physiology, and context of use. Common effects reported by users include feelings of euphoria, increased sociability, enhanced sensory perception, and altered time perception. However, negative effects such as anxiety, paranoia, and physical discomfort have also been reported.
Legal status[edit | edit source]
The legal status of 5-(2-Aminopropyl)indole varies by country. In some countries, it is classified as a controlled substance and its possession, sale, or use is illegal. In others, it is legal to possess but not to sell or distribute.
Health risks[edit | edit source]
As with all psychoactive substances, use of 5-(2-Aminopropyl)indole carries risks. These can include psychological dependence, negative mental health effects, and physical harm due to unsafe behavior while under the influence. There have also been reports of deaths associated with its use, often due to overdose or interaction with other substances.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
