5-Bromouridine

5-Bromouridine (5-BrU) is a nucleoside analogue of uridine that has a bromine atom at the 5 position of the uracil base. It is often used in the laboratory to tag newly synthesized RNA.

Synthesis

5-Bromouridine can be synthesized by reacting uridine with bromine in the presence of phosphorus.

Use in Research

5-Bromouridine is used in research as a tool to label newly synthesized RNA. It is incorporated into the RNA during transcription in place of uridine. The bromine atom can then be detected using autoradiography or immunofluorescence, allowing researchers to visualize the location and amount of new RNA synthesis.

Health Effects

As a brominated compound, 5-bromouridine may have potential health effects. However, these effects are not well studied and more research is needed.

See Also

• Bromouridine
• Uridine
• RNA synthesis
• Transcription (biology)

5-Bromouridine Resources
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