5-HT1A

5-HT1A receptor is a subtype of 5-HT receptor that binds the neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and is located in the central nervous system and peripheral tissues. In the central nervous system, 5-HT1A autoreceptors located on the serotonergic neurons in the raphe nuclei inhibit the release of serotonin. In contrast, 5-HT1A heteroreceptors located in various brain regions are involved in a variety of physiological processes such as the release of other neurotransmitters, the regulation of cognition, mood, and emotion, and the regulation of blood pressure and heart rate.

Function

The 5-HT1A receptor is known to be involved in several neurological and psychiatric disorders such as anxiety, depression, schizophrenia, and Parkinson's disease. Several types of antipsychotics and antidepressants are designed to target this receptor.

Ligands

Many ligands bind to the 5-HT1A receptor to modulate its function. These include agonists, antagonists, and partial agonists. Some of these ligands have therapeutic uses in the treatment of various psychiatric disorders.

See also

• 5-HT receptor
• Serotonin
• Neurotransmitter
• G protein-coupled receptor
• Central nervous system

References

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