5-I-R91150
5-I-R91150 is a radioligand used in neuroscience research, specifically in the study of the serotonin 5-HT2A receptor. It is a selective antagonist for this receptor subtype, meaning it binds to the receptor and blocks its activation by other substances.
Chemistry[edit | edit source]
5-I-R91150 is a derivative of the phenylpiperazine class of compounds. It is structurally related to other 5-HT2A antagonists such as ketanserin and ritanserin, but is distinguished by the presence of an iodine atom at the 5-position of the phenyl ring. This iodine atom allows the compound to be used as a radioligand, as it can be replaced with a radioactive isotope of iodine for imaging studies.
Pharmacology[edit | edit source]
As a 5-HT2A antagonist, 5-I-R91150 inhibits the action of serotonin at this receptor subtype. The 5-HT2A receptor is widely distributed in the brain and is involved in a variety of physiological processes, including mood regulation, cognition, and perception. Antagonists of this receptor have been investigated for their potential in treating psychiatric disorders such as schizophrenia and depression.
Research Use[edit | edit source]
5-I-R91150 is primarily used in Positron Emission Tomography (PET) studies to visualize the distribution of 5-HT2A receptors in the brain. By using a radioactive isotope of iodine to label the compound, researchers can track its binding to the receptor in vivo. This provides valuable information about the density and distribution of 5-HT2A receptors in different brain regions, and how these may be altered in various neurological and psychiatric conditions.
See Also[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
