6-Chloronicotine
6-Chloronicotine is a chemical compound that belongs to the class of nicotine analogs. It is characterized by the substitution of a chlorine atom at the 6-position of the pyridine ring of the nicotine molecule.
Chemical Structure[edit | edit source]
The chemical structure of 6-Chloronicotine consists of a pyridine ring bonded to a pyrrolidine ring, similar to nicotine, but with a chlorine atom replacing a hydrogen atom at the 6-position of the pyridine ring. This modification can significantly alter the compound's pharmacological properties.
Synthesis[edit | edit source]
The synthesis of 6-Chloronicotine typically involves the chlorination of nicotine or its precursors. Various methods can be employed to achieve this, including direct chlorination or the use of chlorinating agents.
Pharmacology[edit | edit source]
6-Chloronicotine interacts with nicotinic acetylcholine receptors (nAChRs) in the central nervous system and peripheral nervous system. The presence of the chlorine atom can affect the binding affinity and efficacy of the compound at these receptors, potentially leading to different biological effects compared to nicotine.
Applications[edit | edit source]
Research into 6-Chloronicotine and other nicotine analogs is ongoing, with potential applications in the development of new pharmacotherapies for nicotine addiction, neurodegenerative diseases, and other conditions where nAChRs play a significant role.
Safety and Toxicity[edit | edit source]
The safety and toxicity profile of 6-Chloronicotine is not well-documented. As with other nicotine analogs, it is important to handle this compound with care and conduct thorough toxicology studies to understand its potential risks.
See also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD