6-IT

6-IT‏‎ (also known as 6-Iodotestosterone) is a synthetic, steroidal androgen that was studied in the 1960s but was never marketed. It is a derivative of testosterone and is specifically the testosterone molecule with an iodine atom added at the 6 position.

History

6-IT was first synthesized and studied in the 1960s. It was found to have potent androgenic activity, but was never marketed. The reason for this is not entirely clear, but it may have been due to its relatively high cost of production compared to other, more easily synthesized androgens.

Pharmacology

As an androgen, 6-IT binds to and activates the androgen receptor, the primary biological target of the androgen sex hormones like testosterone and dihydrotestosterone. This results in a range of effects, including the promotion of male sexual characteristics and the regulation of certain metabolic functions.

Potential Uses

While 6-IT was never marketed, it has been studied for potential use in a number of medical applications. These include the treatment of hypogonadism, a condition in which the body does not produce enough sex hormones, and certain forms of breast cancer that are sensitive to hormones.

Side Effects

Like all androgens, 6-IT has the potential to cause a number of side effects. These can include acne, hair loss, and an increased risk of certain cardiovascular diseases. However, as 6-IT was never marketed, the full range of its potential side effects is not known.

See Also

• Testosterone
• Androgen
• Androgen receptor
• Hypogonadism
• Breast cancer