60S ribosomal protein L30

60S ribosomal protein L30 is a protein that in humans is encoded by the RPL30 gene. This protein is a component of the 60S subunit of the ribosome, playing a critical role in the protein synthesis process. Ribosomes, consisting of two subunits, 40S and 60S, are essential for the translation of mRNA into protein. The 60S ribosomal protein L30 is involved in the assembly and structural stability of the ribosome, facilitating the correct alignment of mRNA and tRNA during translation.

Function

The primary function of the 60S ribosomal protein L30 is to contribute to the structural integrity and function of the ribosome's 60S subunit. It participates in the complex process of protein synthesis, where it may also play a role in the recognition and binding of specific RNA sequences, thus influencing the accuracy of translation. Like other ribosomal proteins, L30 is essential for cellular function and viability, given that protein synthesis is a fundamental process in all living cells.

Gene

The RPL30 gene is located on chromosome 8 in humans. It encodes the 60S ribosomal protein L30, which is highly conserved across different species, indicating its critical role in the ribosome's function. The gene's conservation across species underscores the evolutionary importance of efficient and accurate protein synthesis.

Clinical Significance

Alterations in the expression or function of ribosomal proteins, including L30, can lead to various diseases, known collectively as ribosomopathies. These conditions often result from impaired ribosome biogenesis or function, leading to specific cellular and physiological defects. However, the direct involvement of L30 in specific diseases remains an area of ongoing research.

See Also

• Ribosome
• Protein synthesis
• Ribosomal proteins
• Ribosomopathies