7β-Hydroxy-DHEA
7β-Hydroxy-DHEA is a metabolite of DHEA, a steroid hormone produced by the adrenal gland. It is a neurosteroid, meaning it is produced in the brain and has effects on neuron function.
Structure and Synthesis[edit | edit source]
7β-Hydroxy-DHEA is synthesized from DHEA through the action of the enzyme 7β-hydroxysteroid dehydrogenase. This enzyme is found in high concentrations in the liver and kidney, but is also present in the brain. The structure of 7β-Hydroxy-DHEA is similar to that of DHEA, with the addition of a hydroxyl group at the 7β position.
Function[edit | edit source]
7β-Hydroxy-DHEA has been shown to have neuroprotective effects. It can protect neurons from damage caused by oxidative stress and inflammation. It also has anti-apoptotic effects, meaning it can prevent cell death. In addition, 7β-Hydroxy-DHEA has been shown to enhance memory and cognitive function.
Clinical Significance[edit | edit source]
Research has suggested that 7β-Hydroxy-DHEA may have potential therapeutic applications in the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It may also be beneficial in the treatment of depression and anxiety disorders, as it has been shown to have antidepressant and anxiolytic effects.
See Also[edit | edit source]
References[edit | edit source]
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