7-Hydroxyamoxapine

7-Hydroxyamoxapine is a metabolite of the antidepressant drug amoxapine. It is formed in the body after ingestion of amoxapine, through the process of metabolism. The compound is believed to contribute to the overall antidepressant effect of amoxapine, although its exact role and significance remain under investigation.

Chemistry

7-Hydroxyamoxapine is a dibenzoxazepine derivative, which places it in the same chemical class as other tricyclic antidepressants like loxapine and clozapine. Its chemical structure is characterized by a seven-membered ring with two nitrogen atoms and one oxygen atom, attached to a phenyl ring.

Pharmacology

In the body, 7-Hydroxyamoxapine acts as a reuptake inhibitor, preventing the reabsorption of certain neurotransmitters in the brain. This increases the amount of these neurotransmitters available in the brain, which can help to alleviate symptoms of depression.

The compound is also a potent antagonist of the serotonin 5-HT2A receptor and the dopamine D2 receptor, which are both thought to be involved in the pathophysiology of depression. By blocking these receptors, 7-Hydroxyamoxapine may help to normalize the function of these neurotransmitter systems and reduce depressive symptoms.

Clinical significance

The clinical significance of 7-Hydroxyamoxapine is primarily related to its role as a metabolite of amoxapine. The drug amoxapine is used in the treatment of major depressive disorder, and the formation of 7-Hydroxyamoxapine in the body is a key part of its mechanism of action.

However, the compound may also have some direct clinical effects. Some research suggests that 7-Hydroxyamoxapine may have antipsychotic properties, due to its ability to block dopamine D2 receptors. This could potentially make it useful in the treatment of conditions like schizophrenia, although more research is needed to confirm this.

See also

• Amoxapine
• Metabolism
• Antidepressant
• Dopamine
• Serotonin

The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone