7-Keto-DHEA

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A metabolite of the hormone dehydroepiandrosterone (DHEA)



7-Keto-DHEA is a metabolite of the hormone dehydroepiandrosterone (DHEA). It is known for its potential role in thermogenesis, weight loss, and immune system enhancement. Unlike DHEA, 7-Keto-DHEA does not convert into estrogen or testosterone in the body, which makes it a popular choice for those seeking the benefits of DHEA without the associated hormonal effects.

Biochemistry[edit | edit source]

7-Keto-DHEA is produced in the body from DHEA through the action of the enzyme 11_-hydroxysteroid dehydrogenase. It is primarily found in the adrenal glands, skin, and brain. The compound is known to enhance the activity of thermogenic enzymes, which are involved in the process of heat production in the body.

Mechanism of Action[edit | edit source]

7-Keto-DHEA is believed to work by increasing the activity of thermogenic enzymes such as glycerol-3-phosphate dehydrogenase and malic enzyme. These enzymes play a role in the metabolism of fatty acids and the production of adenosine triphosphate (ATP), the energy currency of the cell. By enhancing these processes, 7-Keto-DHEA may help increase metabolic rate and promote weight loss.

Potential Benefits[edit | edit source]

Weight Loss[edit | edit source]

7-Keto-DHEA is often marketed as a weight loss supplement due to its ability to increase metabolic rate. Studies suggest that it may help reduce body weight and body fat when combined with a calorie-restricted diet and exercise.

Immune System Support[edit | edit source]

There is some evidence to suggest that 7-Keto-DHEA may enhance immune function. It is thought to do this by increasing the production of cytokines, which are signaling molecules that help regulate the immune response.

Cognitive Function[edit | edit source]

Some research indicates that 7-Keto-DHEA may have a positive effect on cognitive function and memory. This is thought to be due to its ability to modulate neurotransmitter levels in the brain.

Safety and Side Effects[edit | edit source]

7-Keto-DHEA is generally considered safe when used as directed. However, some individuals may experience side effects such as nausea, dizziness, or headache. It is important to consult with a healthcare provider before starting any new supplement regimen.

Related pages[edit | edit source]

Gallery[edit | edit source]

  • Structure of 7-Keto-DHEA

  • Structure of 7-Keto-DHEA acetate

  • 7-Keto-DHEA

  • 7-Keto-DHEA acetate

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Contributors: Prab R. Tumpati, MD