A-80426
A-80426 is a chemical compound that acts as a potent and selective dopamine receptor agonist. It is primarily used in scientific research to study the role of dopamine receptors in the brain and their involvement in various neurological and psychiatric disorders.
Chemical Properties[edit | edit source]
A-80426 is a synthetic compound with a complex chemical structure designed to selectively target dopamine receptors. The exact molecular formula and structure are proprietary, but it is known to have high affinity for the D2 and D3 subtypes of dopamine receptors.
Pharmacology[edit | edit source]
A-80426 functions as an agonist at dopamine receptors, meaning it binds to these receptors and activates them, mimicking the action of the neurotransmitter dopamine. This action makes it a valuable tool in research for understanding the dopaminergic system, which is implicated in conditions such as Parkinson's disease, schizophrenia, and addiction.
Mechanism of Action[edit | edit source]
The mechanism of action of A-80426 involves its binding to the D2 and D3 dopamine receptors, which are G-protein coupled receptors (GPCRs). Upon binding, A-80426 induces a conformational change in the receptor, leading to the activation of intracellular signaling pathways that modulate neuronal activity and neurotransmitter release.
Research Applications[edit | edit source]
A-80426 is used in preclinical studies to:
- Investigate the role of dopamine in motor control and reward pathways.
- Explore potential therapeutic targets for treating dopamine-related disorders.
- Study the effects of dopamine receptor activation on behavior and cognition.
Safety and Toxicology[edit | edit source]
As a research chemical, A-80426 is not approved for human use. Its safety profile is not fully characterized, and it should be handled with caution in laboratory settings. Researchers must adhere to appropriate safety protocols when working with this compound.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
