ABCC10

ABCC10 also known as Multidrug Resistance Protein 7 (MRP7) is a protein that in humans is encoded by the ABCC10 gene. It is a member of the superfamily of ATP-binding cassette transporters (ABC transporters), which transport various molecules across extra- and intra-cellular membranes.

Function

ABCC10 is involved in multi-drug resistance; it likely serves as a cellular defense mechanism against xenobiotics. The protein is an ATP-dependent efflux pump with broad substrate specificity, able to transport a variety of drugs from the cytoplasm. These drugs include paclitaxel, vincristine, methotrexate, and epothilone B.

Clinical Significance

Alterations in the ABCC10 gene are associated with drug resistance in many cancers. For example, overexpression of ABCC10 has been observed in paclitaxel-resistant cancer cells. Therefore, ABCC10 is a potential target for overcoming drug resistance in cancer treatment.

Structure

The ABCC10 protein is composed of 1492 amino acids and has a molecular mass of approximately 165 kDa. It has two homologous halves, each with six transmembrane segments and a nucleotide binding domain (NBD). The NBDs contain the characteristic motifs of ABC transporters, which are involved in ATP binding and hydrolysis.

See Also

• ATP-binding cassette transporter
• Multidrug resistance

External Links

• NCBI Gene
• UniProt