ABHD6

ABHD6 (Alpha/Beta Hydrolase Domain Containing 6) is a protein that in humans is encoded by the ABHD6 gene. This protein is part of the serine hydrolase family of enzymes, which are involved in a variety of biological processes, including lipid metabolism and inflammation.

Function

ABHD6 is a lipase that is primarily located in the mitochondria of cells. It plays a crucial role in the regulation of endocannabinoid signaling pathways by controlling the levels of 2-arachidonoylglycerol (2-AG), a major endocannabinoid. By hydrolyzing 2-AG, ABHD6 helps to regulate the duration and intensity of endocannabinoid signaling.

Clinical Significance

Research has suggested that ABHD6 may be a potential therapeutic target for the treatment of obesity and related metabolic disorders. Inhibition of ABHD6 has been shown to increase levels of 2-AG, which can enhance insulin sensitivity and reduce inflammation. However, further research is needed to fully understand the potential therapeutic applications of targeting ABHD6.

See Also

• Serine hydrolase
• Endocannabinoid system
• Lipid metabolism

References

‎

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian