ADAMDEC1

ADAMDEC1 is a gene that encodes a member of the ADAM (A Disintegrin And Metalloprotease Domain) family. Members of this family are involved in a variety of biological processes involving cell-cell and cell-matrix interactions, including cell adhesion and cell migration. ADAMDEC1 is a unique member of the ADAM family in that it lacks metalloprotease activity due to changes in its catalytic site.

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Location of the ADAMDEC1 gene on human chromosome 8.

Function

The ADAMDEC1 gene is expressed in lymphoid tissue and encodes a protein that is localized to the extracellular matrix (ECM). The protein plays a role in the regulation of immune response and inflammation. It is thought to modulate the inflammatory response by cleaving molecules on the surface of leukocytes.

Clinical Significance

Alterations in the expression of the ADAMDEC1 gene have been associated with various diseases. For example, increased expression of ADAMDEC1 has been observed in rheumatoid arthritis and colorectal cancer. In contrast, decreased expression of ADAMDEC1 has been reported in breast cancer. The exact role of ADAMDEC1 in these diseases is still under investigation.

Research

Current research is focused on understanding the precise function of ADAMDEC1 and its role in disease. This includes studying the protein's structure, its interactions with other proteins, and its role in cell processes such as adhesion and migration.

See Also

• ADAM Protein
• Metalloprotease
• Extracellular Matrix
• Cell Adhesion
• Cell Migration