ADAMTS6

ADAMTS6 is a protein that in humans is encoded by the ADAMTS6 gene. ADAMTS6 belongs to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteins. These proteins are known to have a wide range of functions, including the breakdown of extracellular matrix, inhibition of angiogenesis, and the control of organogenesis.

Function

ADAMTS6 is an enzyme that is part of the ADAMTS family. This family is known for its role in the breakdown of the extracellular matrix, a three-dimensional network of extracellular macromolecules such as collagen, enzymes, and glycoproteins that provide structural and biochemical support to surrounding cells.

In addition to its role in the extracellular matrix, ADAMTS6 has been implicated in a variety of biological processes. For example, it has been suggested to play a role in organogenesis, the process by which the embryo develops into a fully formed organism.

Clinical significance

Mutations in the ADAMTS6 gene have been associated with a variety of medical conditions. For example, some studies have suggested a link between ADAMTS6 and certain types of cancer, including breast cancer and colorectal cancer. However, more research is needed to fully understand the role of ADAMTS6 in these conditions.

See also

• ADAMTS
• Extracellular matrix
• Organogenesis

References

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