Adenine nucleotide translocator
(Redirected from ADP/ATP translocase)
Adenine Nucleotide Translocator
The Adenine Nucleotide Translocator (ANT), also known as the Adenine Nucleotide Carrier (ANC), is an integral membrane protein that facilitates the exchange of adenine nucleotides across the mitochondrial inner membrane.
Structure[edit | edit source]
The ANT is a transmembrane protein composed of six alpha-helices. The protein is embedded in the inner mitochondrial membrane, with its major axis perpendicular to the plane of the membrane. The ANT has a molecular weight of approximately 30 kDa and is composed of about 300 amino acids.
Function[edit | edit source]
The primary function of the ANT is to exchange adenosine triphosphate (ATP) produced in the mitochondria with adenosine diphosphate (ADP) from the cytosol. This exchange is crucial for cellular energy metabolism, as it allows the ATP produced in the mitochondria to be used by the rest of the cell, while the ADP is returned to the mitochondria for conversion back into ATP.
Clinical Significance[edit | edit source]
Mutations in the genes encoding the ANT can lead to various diseases, including cardiomyopathy, neuropathy, and lactic acidosis. In addition, the ANT has been implicated in the process of apoptosis, or programmed cell death.
See Also[edit | edit source]
References[edit | edit source]
Adenine nucleotide translocator Resources | |
---|---|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prabhudeva