ADX-71441

ADX-71441 is a drug that acts as a positive allosteric modulator at the gamma-aminobutyric acid type B (GABA_B receptor). It has anxiolytic and anti-addictive effects in animal studies, and has been used to study the role of the GABA_B receptor in various processes including anxiety, depression, drug addiction, and neuropathic pain.

Pharmacology

ADX-71441 is a positive allosteric modulator of the GABA_B receptor, which means it enhances the effect of the natural neurotransmitter GABA at this receptor. This is in contrast to agonist drugs, which directly activate the receptor, and antagonist drugs, which block the receptor. Positive allosteric modulators have the advantage of only enhancing the natural activity of the receptor, rather than fully activating or blocking it, which can lead to fewer side effects.

Therapeutic potential

In animal studies, ADX-71441 has shown potential for the treatment of anxiety, depression, drug addiction, and neuropathic pain. It has been shown to reduce anxiety-like behavior in mice, and to reduce alcohol-seeking behavior in rats. It has also been shown to have antidepressant-like effects in a mouse model of depression, and to reduce pain in a rat model of neuropathic pain.

See also

• GABA_B receptor
• Positive allosteric modulator
• Anxiolytic
• Anti-addictive

References

ADX-71441 Resources
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