AKR7A3

AKR7A3 is a gene that encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of a number of aldehydes, including the aldehyde form of vitamin A, retinal, and is expressed at high levels in the adrenal gland and liver, and at lower levels in the testis and brain.

Function

The AKR7A3 gene is part of the aldo/keto reductase superfamily. Members of this family are involved in the detoxification of aldehydes and ketones, which are reactive compounds that can cause damage to cells. The AKR7A3 enzyme uses NADPH, a molecule that carries electrons, to convert these harmful compounds into less reactive substances.

Clinical significance

Mutations in the AKR7A3 gene have been associated with a variety of diseases, including cancer, diabetes, and neurodegenerative diseases. The exact role of AKR7A3 in these diseases is still under investigation, but it is thought to be involved in the metabolism of certain toxic compounds and drugs.

See also

• Aldo-keto reductase
• NADPH
• Aldehyde

External links

• AKR7A3 at NCBI
• AKR7A3 at GeneCards