ALDH3B1

ALDH3B1 is a gene that encodes a member of the aldehyde dehydrogenase family, a group of enzymes that are involved in the metabolism of aldehydes. The ALDH3B1 gene is located on chromosome 11 in humans and is expressed in a variety of tissues, including the liver, kidney, and heart.

Function

The enzyme encoded by the ALDH3B1 gene is responsible for the oxidation of aldehydes to their corresponding acids. This process is important in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme also plays a role in the metabolism of retinol, a form of vitamin A, in the eye.

Clinical significance

Mutations in the ALDH3B1 gene have been associated with various diseases. For example, a study found that a specific mutation in this gene was associated with an increased risk of alcoholism. Other studies have suggested a link between ALDH3B1 and certain types of cancer, including breast and lung cancer.

Research

Research into the ALDH3B1 gene and its associated enzyme is ongoing. Scientists are particularly interested in understanding how variations in this gene may influence the risk of disease and the body's response to certain drugs.

See also

• Aldehyde dehydrogenase
• Alcohol dehydrogenase
• Retinol