ALK7
ALK7 is a type of protein that in humans is encoded by the ACVR1C gene. It is also known as Activin receptor type-1C. This protein is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases.
Function[edit | edit source]
The ligands of this receptor are members of the TGF-beta superfamily. TGF-beta related proteins such as activin and BMPs are involved in a wide range of biological processes including cell proliferation, apoptosis, and differentiation.
ALK7 has been shown to interact with Follistatin and Inhibin, two proteins that regulate the actions of activin. This receptor is predominantly expressed in the adipose tissue, suggesting that it may play a role in the regulation of adipogenesis.
Clinical Significance[edit | edit source]
Mutations in the ALK7 gene have been associated with various medical conditions. For example, a mutation in this gene has been linked to pre-eclampsia, a condition in pregnant women characterized by high blood pressure and damage to other organ systems.
In addition, studies have suggested that ALK7 may play a role in the development of type 2 diabetes. This is because the protein is involved in the regulation of insulin secretion and sensitivity, which are key factors in the development of this disease.
See Also[edit | edit source]
References[edit | edit source]
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