ANGPTL3
ANGPTL3 (Angiopoietin-like 3) is a protein that in humans is encoded by the ANGPTL3 gene. It is a member of the angiopoietin-like family of secreted factors. ANGPTL3 is involved in lipid metabolism, and its inhibition has been associated with decreased levels of triglycerides and low-density lipoprotein cholesterol (LDL-C).
Function[edit | edit source]
ANGPTL3 is a protein that is secreted by the liver and has been shown to inhibit lipoprotein lipase (LPL) and endothelial lipase (EL), enzymes involved in the metabolism of triglycerides and high-density lipoprotein cholesterol (HDL-C). By inhibiting these enzymes, ANGPTL3 increases the levels of triglycerides and decreases the levels of HDL-C in the blood.
Clinical significance[edit | edit source]
Mutations in the ANGPTL3 gene have been associated with familial combined hypolipidemia, a condition characterized by abnormally low levels of cholesterol and triglycerides in the blood. In addition, inhibition of ANGPTL3 has been proposed as a potential therapeutic strategy for the treatment of hyperlipidemia and atherosclerosis.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
ANGPTL3 Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD